What business credit card is best for $250,000 month spend for travel?

Sorry Dewy, I'm not sure what you're trying to ask there, but if you meant to ask whether AMEX credit cards and AMEX charge cards are processed in the same way by merchants, the answer is yes: to them, you're simply paying by AMEX.

Unlike Visa and Mastercard which can charge fees at a whole host of different processing rates depending on where the card is from, the type of card and so on, in Australia, businesses normally pay a set fee to process AMEX transactions, which is the same whether it's a credit card or a charge card / a business, personal, corporate or government card / a standard, gold, platinum or 'black' card, and so on. As a fun piece of trivia, businesses that accept AMEX in Australia can also automatically accept JCB cards, which are processed over the same network as AMEX with the same transaction fee as AMEX, which is handy for businesses who get lots of customers from Japan, particularly those in the tourism and leisure industries.